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TSMB General Books

Some Useful References for the Course

These are books you might find helpful, but they do not define the syllabus. The syllabus is what is presented in the Web Pages and links contained in them. Most of these books are for reference rather than purchase. Probably Physical Biochemistry by David Sheehan (see below) comes closest to covering the course if you want to buy one book, but there are sections it does not include

Protein Structure

Introduction to Protein Structure, Branden, C. and Tooze, J. (1999) 2nd edition, Garland Publishing, New York.

Protein Structure and Function. Petsko, G and Ringe, D. (2003) New Science Press/Blackwell Publishing

Introduction to Protein Architecture: The Structural Biology of Proteins Lesk, A. (2000) Oxford University Press. A recent alternative.

The Oxford Practical Approach Series from OUP offers detailed books on the various techniques covered. These are usually not too mathematically complex and are a good guide as to what to do practically.

General and Biochemical

Protein Function: A practical Approach (1997) Tom Creighton ISBN 0-19-963615-X

Physical Biochemistry: Principles and Applications David Sheehan (2000) Wiley ISBN 0-471-98663-1


Bioinformatics: Sequence, Structure and Databanks (2000) Ed by Des Higgins, and Willie Taylor

Protein Purification and Analysis

Protein Purification Techniques New Edition (2000) Edited by Simon Roe

Gel Electrophoresis of Proteins Edited by B. D. Hames 3rd Edition


Crystallization of Nucleic Acids and Proteins Ed Ducruix, A and Giegé, R. 2nd Edition


NMR of Macromolecules (1993) Edited by Gordon C. K. Roberts



Other Books

Molecular Biology

Molecular Cloning: A Laboratory Manual (Third Edition) By Joe Sambrook, and David Russell. Cold Spring Harbor Press ISBN 0-87969-577-3. This is the latest edition of what is usually known as ‘Maniatis’ who was the final author of the first two editions. It is the ‘bible’ of molecular biology but is very expensive


Biomolecular NMR Spectroscopy. Jeremy N. S. Evans (1995) OUP. This was an excellent textbook when it came out but some of it is starting to be dated.


Crystallography Made Crystal Clear Gale Rhodes (1999) 2nd Edition Academic Press ISBN 0-125870728

A very good guide made by a leading teacher of macromolecular structure.

Biophysical Techniques

Physical Biochemistry: Principles and Applications David Sheehan (2000) Wiley ISBN 0-471-98663-1. Possibly the single most approriate book for this course.

C. Cantor and P.R. Schimmel 3 volumes (1980) WH Freeman. Still one of the best and most detailed texts.

Part I: The Conformation of Biological Macromolecules ISBN 0-7167-1188-5

Part II: Techniques for the Study of Biological Structure and Function ISBN 0-7167-1190-7

Part III: The Behavior of Biological Macromolecules ISBN 0-7167-1192-3